Spray Pattern and Plume Geometry

Spray Pattern and Plume Geometry

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  • Category : Inhaled Drug

<p>Have you ever wondered what shape the spray or aerosol you have really produces from your MDI/DPI or NSP? For a variety of reasons, these drug delivery methods need characterization. Following is a piece of information from CMC guideline on the importance of Spray Pattern and Plume Geometry analysis. Characterization of spray pattern and plume geometry is important for evaluating the performance of the pump. Various factors can affect the spray pattern and plume geometry, including the size and shape of the nozzle, the design of the pump, the size of the metering chamber, and the characteristics of the formulation. Spray pattern testing should be performed on a routine basis as a quality control for release of the drug product. However, the characterization of plume geometry typically should be established during the characterization of the product and is not necessarily tested routinely thereafter.<br /><br /> Ref: <em>"Guidance for Industry Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products -<br /> Chemistry, Manufacturing, and Controls Documentation"</em><br /> U.S. Department of Health and Human Services, Food and Drug Administration,<br /> Center for Drug Evaluation and Research (CDER), July 2002.</p>

Metered Dose Inhaler (MDI), Dry Powder Inhaler (DPI), Nasal Spray (NSP)

A Spray pattern capturing systems captures images of the spray from front and calculates how it looks in front view when sprayed. The patterns may be elliptical, circular, flat spray, hollow cone and so on. The plume geometry identifies the angle of spray. It gives an idea how widely the spray droplets are delivered.

Have you ever wondered what shape the spray or aerosol you have really produces from your MDI/DPI or NSP? For a variety of reasons, these drug delivery methods need characterization. Following is a piece of information from CMC guideline on the importance of Spray Pattern and Plume Geometry analysis. Characterization of spray pattern and plume geometry is important for evaluating the performance of the pump. Various factors can affect the spray pattern and plume geometry, including the size and shape of the nozzle, the design of the pump, the size of the metering chamber, and the characteristics of the formulation. Spray pattern testing should be performed on a routine basis as a quality control for release of the drug product. However, the characterization of plume geometry typically should be established during the characterization of the product and is not necessarily tested routinely thereafter.


BIO-XIN state-of-the-art equipments for spray pattern and plume geometry are specially engineered for pharmaceutical application. The instruments are complaint with ISO 13320-1 and CFR 21 rule 11.